BTX modification of Na channels in squid axons. I. State dependence of BTX action.

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BTX modification of Na channels in squid axons. I. State dependence of BTX action

The state dependence of Na channel modification by batrachotoxin (BTX) was investigated in voltage-clamped and internally perfused squid giant axons before (control axons) and after the pharmacological removal of the fast inactivation by pronase, chloramine-T, or NBA (pretreated axons). In control axons, in the presence of 2-5 microM BTX, a repetitive depolarization to open the channels was req...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 1991

ISSN: 0022-1295,1540-7748

DOI: 10.1085/jgp.97.3.499